ImproveAssembly - Tool for identifying new gene products and improving genome assembly
نویسندگان
چکیده
منابع مشابه
The C.A.Ve. Software Tool for Genome Assembly
Misassembly due to the presence of repetitive DNA sequences often complicates the contig assembly stage of genome sequencing. Accurate physical representations of chromosomes, such as restriction maps or contig maps, provide a means for validating the sequence assembly and clarifying alignment ambiguity. The Contig Assembly Verifier (CAVe) software tool allows the researcher to automatically re...
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Most reconstruction methods for genomes of ancient origin that are used today require a closely related reference. In order to identify genomic rearrangements or the deletion of whole genes, de novo assembly has to be used. However, because of inherent problems with ancient DNA, its de novo assembly is highly complicated. In order to tackle the diversity in the length of the input reads, we pro...
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Assembly of genomes from whole-genome sequencing (WGS) projects is one of the most complex computational problems in genomics. WGS assemblers such as Arachne [1] and Celera Assembler [2] are able to process data from millions of individual sequence "reads" and construct an accurate representation of a genome. These assemblies are in the form of contigs (contiguous stretches of DNA sequence) and...
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MOTIVATION Efficient and fast next-generation sequencing (NGS) algorithms are essential to analyze the terabytes of data generated by the NGS machines. A serious bottleneck can be the design of such algorithms, as they require sophisticated data structures and advanced hardware implementation. RESULTS We propose an open-source library dedicated to genome assembly and analysis to fasten the pr...
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Many disease genes encode proteins that are difficult to target directly using small molecule drugs. Improvements in libraries based on synthetic compounds, natural products, and other types of molecules may ultimately allow some challenging proteins to be successfully targeted; however, these developments alone are unlikely to be sufficient. A complementary strategy exploits the functional int...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0206000